Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder

A Fornito; M Yücel; SJ Wood; A Bechdolf; S Carter; C Adamson; D Velakoulis; MM Saling; PD McGorry; C Pantelis

Journal article

Anterior cingulate cortex abnormalities associated with a first psychotic episode in bipolar disorder

A Fornito, M Yücel, SJ Wood, A Bechdolf, S Carter, C Adamson, D Velakoulis, MM Saling, PD McGorry, C Pantelis

British Journal of Psychiatry | Published : 2009

DOI: 10.1192/bjp.bp.107.049205

Abstract

Background The anterior cingulate cortex is frequently implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies have reported variable findings owing to a reliance on patient samples with chronic illness and to limited appreciation of the region's heterogeneity. and 26 healthy controls matched for age, gender and regional morphological variability. Aims To characterise anterior cingulate cortex abnormalities in patients with bipolar disorder experiencing their first episode of psychosis while accounting for regional anatomical variability. Results Relative to controls, male patients displayed increased thickness in the right subcallosal limbic anter..

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University of Melbourne Researchers

Stephen Wood Author

Dennis Velakoulis Author

Michael Saling Author

Patrick McGorry Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This research was supported by the Melbourne Neuroosychiatry Centre (Sunshine Hospital), Department of Psychiatry, The University of Melbourne. the National Health and Medical Research Council (NHMRC) (ID 236175; 350241): and the Ian Potter Foundation. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory managed by Ms Bridget Soulsby at. the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria S.J,W. was supported by a NHMRC Clinical Career Development Award and a NARSAD Young Investigator Award. A.F. was supported by a JN Peters Fellowship and a NHMRC CJ Martin Fellowship (ID 454 97)